Pitfalls of Meta-Analyses

A brief methodological commentary on the retraction of our homeopathy ADHD meta-analysis

We had rejoiced too soon. Last summer, I reported that we were able to publish a meta-analysis on homeopathy in ADHD, which showed a significant effect size of g = 0.6 [1]. It was recently retracted by the journal, not by us.

The background: We had made an extraction error, namely positively coding an effect size that should actually be negatively coded. This is one of the pitfalls in a meta-analysis that I have now stumbled across myself. Because you always have to ask yourself: Do the effects of a study point in the direction of the hypothesis, i.e. do they support the assumption that the difference speaks for the effectiveness of a treatment, or against it? In this case [2], the result was not only not significant in favor of homeopathy, but even pointed in the other direction. This should have been marked with a minus sign in the analysis, which I had simply overlooked. And my colleagues didn’t notice it either, so this very stupid mistake crept in.

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Mistletoe Therapy And Quality of Life in Breast Cancer

Our new meta analysis is published

Mistletoe therapy is popular among patients in German-speaking countries as an adjunct treatment for cancer. This is due to the fact that Ita Wegmann, an associate of Rudolf Steiner, had introduced mistletoe into medical cancer therapy at his suggestion. Steiner used, besides the knowledge of old European healing traditions, mainly his intuition and the mistletoe’s signature: mistletoe grows parasitically on trees and feeds on the host tree, which slowly but surely perishes. So according to the ancient signature theory and its phenomenology, mistletoe should also work on humans for a similar disease, namely cancer, which is also a parasitic growth in the body.

Early studies

In the 1970s and 1980s, much basic research was done on mistletoe extracts. This showed that mistletoe contains an abundance of immunologically relevant substances, so-called lectins, which activate the immune system [1]. At that time, the first clinical studies began, in which physicians – especially those with an anthroposophical orientation – used mistletoe therapeutically in cancer patients. Initially, this was often done in rather severe cases with terminal cancer. Since then there has been a whole series of investigations. In 2020, my colleague Thomas Ostermann published in our journal Complementary Medicine Research a meta-analysis of all clinical trials in which a particular fermented mistletoe preparation, Iscador, had been used with all kinds of cancer types and in which survival was measured [2]. This publication was an update of a previously published study and included new studies, for a total of 32, both randomized and non-randomized comparative studies. The hazard ratio was 0.59, pretty much the same as in the earlier analysis.

The hazard ratio quantifies the difference between treatment group and control group (mostly normal treatment) over time. In this case, it means that patients treated with Iscador are 41% more likely to survive longer, meaning they live significantly longer. (It is not possible to estimate how long patients live longer overall in such analyses because observation durations vary widely. Therefore, one can only gain an estimate of the probability of living longer and a hedge on whether that probability is more than a random fluctuation.)

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Self-Amplifying RNA Shots Are Coming: The Untold Danger

The truth behind RNA-based vaccine technology (Part 2)

From time to time, I publish contributions from other scientists and authors who seem to me to be appropriate to topics that are of current concern to me and on which I myself can provide less competent information. Prof. Klaus Steger is a molecular biologist and has published a three-part article on Covid-19 vaccines and the active principles of modRNA (nucleoside-modified mRNA) in the English version of “Epoch-Times”. I find these texts very informative.

Harald Walach

The original article is available at Epoch-Times (follow this link)

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COVID-19 Vaccines and Boosters Were Never Made With mRNA

The truth behind RNA-based vaccine technology (Part 1)

From time to time, I publish contributions from other scientists and authors who seem to me to be appropriate to topics that are of current concern to me and on which I myself can provide less competent information. Prof. Klaus Steger is a molecular biologist and has published a three-part article on Covid-19 vaccines and the active principles of modRNA (nucleoside-modified mRNA) in the English version of “Epoch-Times”. I find these texts very informative.

Harald Walach

The original article is available at Epoch-Times (follow this link)

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My Last Wishes for Germany

I have already said goodbye to Germany once under this title. That was in 2005, in my farewell lecture from Freiburg. At that time, I went to England because German university legislation made it impossible for me to continue financing my position as a non-scheduled professor at the University Hospital in Freiburg with my third-party funds, which I possessed sufficiently. I found England very congenial. The colleagues were friendly and collegial. There was almost a conspiratorial community spirit. I soon realized why, and that’s what drove me out of England 5 years later: The system there is divided into academics – those who add value by teaching and researching and thus earning the money that keeps the university going – and administrators and managers – who tell academics what to do. German academics have it better in that regard. At least in theory, they are free in their research and teaching. In addition, the English system is extremely hierarchical and reflects the English class society: There are the universities at the top, Oxford, Cambridge, Imperial, Queen Mary, University College, the excellent universities of the Russell Group, and a host in the back ranks. The top universities take in just under 50% of their students, mainly the best students from the 7% or so English private schools (they are not allowed to take in more of these, otherwise they lose their grants from the state; I have reflected on these connections elsewhere [1, 2]). The pupils of these private schools are, with very few exceptions, those from rich homes. This is because the tuition for such schools costs at least a year’s salary of an average wage earner. (When I was in Northampton, the average annual income in the area was £27,000; the local private school would have cost £25,000 a year, and it was still one of the cheapest in the country). In this way, the English class system distills upward. In the country’s good universities, the upper classes meet. That’s how the social system is fixed.

When I understood this at that time, I decided, if there was an opportunity, to return to Germany, where I experienced a very egalitarian university system and a permeable education system, the quality of which did not depend on the income of the parents. As a child of simple parents with a farming background and no tutoring from home, I was able to graduate from a good school and study without paying fees. To this system, I wanted to give back something of what I once received myself.

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